Member Companies

Biose Industrie is a Contract Development and Manufacturing Organization (CDMO), specialized in Live Biotherapeutic Products. Founded in 1951 by pharmacists and microbiologists, Biose Industrie has more than 60 years of experience in the development and production of live bacteria-based drugs. The company offers lab development specialised in microbiology and is Drug GMP certified for the manufacturing of API, clinical batches and commercial products.

BiomeSense is revolutionizing human microbiome research by creating novel tools to track, analyze, and store daily microbiome profiles of clinical trial participants, providing vastly more data than is possible with current tools, all for a fraction of the cost. This gives investigators far deeper insight into how the microbiome influences and is influenced by clinical interventions.

Freya™ is a clinical-stage biotech company taking an innovative approach to women’s health, with microbial immunotherapies aimed at relieving the chronic inflammation underlying a range of reproductive system diseases uniquely afflicting women. Freya’s drug candidates comprise full-spectrum microbiota and rationally-selected strain consortia, which have the potential to restore an optimal, non-inflammatory vaginal microbiome. Freya has completed two proof-of-concept studies, as well as a prospective cohort study in IVF, expanding biomarker data in the initial target population, and feeding into the company’s multi-omics data platform. Freya’s next generation therapeutics are currently in development and will be tested in clinical trials in the near future. Freya was established in 2020 and has headquarters in Copenhagen, Denmark and Boston, Massachusetts.

Genetic Analysis (GA) is a molecular diagnostic company with core focus within microbiome and has developed and launched the GA-map® Platform for gut microbiome analysis. The first marker is the GA-map Dysbiosis Test, the first documented CE marked routine test to identify and characterize the gut microbiota composition, initially targeted at IBS and IBD patients. The results are immediately compared to a clinical validated normal healthy population through the advanced GA-map® software algorithm. This enables immediate results without any further bioinformatics work needed. GA-map® is currently the only routine diagnostic tool for microbiota.

Commercialisation has started on the European and US market and the GA-map® Test platform will increase the efficiency in the Lab and provide customers with superb quality results that is unique within the microbiome diagnostics area.

GA collaborates with pharma companies and academia in research projects for product documentation, new marker discovery and clinical research.

GA has new biomarker development projects ongoing in order to utilize the platform for other disease areas and has a unique bio-Bank with more than 7000 samples within different cohorts i.e; Healthy normals, IBD, Cdiff, IBS, Diabetes T2, RA, Parkinson.

MaaT Pharma is a leading, late-stage clinical company focused on developing innovative gut microbiome-driven therapies to modulate the immune system and enhance cancer patient survival. Supported by a talented team committed to making a difference for patients worldwide, the Company was founded in 2014 and is based in Lyon, France.

As a pioneer, MaaT Pharma is leading the way in bringing the first microbiome-driven immunomodulator in oncology. Using its proprietary pooling and co-cultivation technologies, MaaT Pharma develops high diversity, standardized drug candidates, aiming at extending life of cancer patients. MaaT Pharma has been listed on Euronext Paris (ticker: MAAT) since 2021.

Microba Life Sciences is a pre-clinical precision microbiome science company taking a human-first, data-driven approach to therapeutic discovery. Powered by precision analysis, Microba’s therapeutic discovery platform uses human data and leading informatic approaches to connect microbial genotype to human phenotype. Pioneered by our founders, our unique approach to culturing novel bacteria through genome-directed isolation provides us with novel disease-relevant bacterial isolates. The lead candidates derived from the human first, data driven approach have achieved excellent results and are being prepared for human trials.

Nestlé Health Science, a leader in the science of nutrition, is a globally managed business unit of Nestlé. We are committed to redefining the management of health, offering an extensive portfolio of science-based consumer health, medical nutrition, pharmaceutical therapies, and vitamin and supplement brands. Our extensive research network provides the foundation for products that empower healthier lives through nutrition. Headquartered in Switzerland, we have more than 12,000 employees around the world, with products available in more than 140 countries.

In 2023, it launched VOWST, the first orally approved microbiome therapy administered orally for the prevention of C. diff recurrence delivered in oral capsules to help prevent recurrence of Clostridioides difficile infection in people 18 years of age or older after antibiotic treatment for C. diff infection has been completed.

Rebiotix Inc, which is part of the Ferring Pharmaceuticals Group, is a late-stage clinical microbiome company focused on harnessing the power of the human microbiome to revolutionize the treatment of debilitating diseases. Rebiotix possesses a deep and diverse clinical pipeline, with its lead drug candidate, RBX2660, in Phase 3 clinical development for the prevention of recurrent Clostridium difficile (C. diff) infection. RBX2660 has been granted Fast Track status, Orphan Drug and Breakthrough Therapy designation from the FDA for its potential to prevent recurrent C. diff infection. Rebiotix’s clinical pipeline also features RBX7455, a lyophilized non-frozen, oral capsule formulation, which is currently moving into a Phase 2 IND trial for the prevention of recurrent C. diff infection having completed an investigator sponsored Phase 1 study. In addition, Rebiotix is targeting several other disease states with drug products built on its pioneering Microbiota Restoration Therapy™ platform. The MRT™ platform is a standardized, stabilized drug technology that is designed to rehabilitate the human microbiome by delivering a broad consortium of live microbes into a patient’s intestinal tract via a ready-to-use and easy-to-administer format.

Seres Therapeutics, Inc. (Nasdaq: MCRB) is a leading microbiome therapeutics platform company developing a novel class of biological drugs that are designed to treat disease by restoring the function of a dysbiotic microbiome, where the state of bacterial diversity and function is imbalanced. Seres’ SER-287 program has obtained Fast Track and Orphan Drug designation from the U.S. Food and Drug Administration and is being evaluated in a Phase 2b study in patients with active mild-to-moderate ulcerative colitis. Seres’ SER-109 program has obtained Breakthrough Therapy and Orphan Drug designations from the FDA and is in Phase 3 development for recurrent C. difficile infection. Seres is also developing SER-401 in a Phase 1b study in patients with metastatic melanoma.

Siolta Therapeutics is a clinical-stage biotech company on a mission to alleviate the suffering of millions impacted by chronic inflammatory diseases through novel microbiome-based medicines. Siolta leverages its deep knowledge of the developing infant gut microbiome and its role in promoting immune tolerance to develop targeted microbial therapeutics and companion diagnostics for the prevention and treatment of inflammatory diseases. The company’s blended expertise from microbiology, immunology, and bioinformatics supports the development of a multifaceted platform, integrating ecosystems approaches and precision medicine concepts to advance the future of medicine. Currently focused on the clinical development of their lead product for the prevention and treatment of allergic asthma, Siolta’s holistic, microbiome-based strategy represents a new frontier in the pursuit of tailored, clinically differentiated microbial therapeutics.

Vedanta Biosciences is developing a new category of therapies for immune-mediated and infectious diseases based on rationally defined consortia of human microbiome-derived bacteria. Vedanta Biosciences is a leader in the microbiome field with capabilities and deep expertise to discover, develop, and manufacture live bacteria drugs. These include what is believed to be the largest collection of human microbiome-associated bacterial strains, a suite of proprietary assays to select pharmacologically potent strains, vast proprietary datasets from human interventional studies, and facilities for cGMP-compliant manufacturing of rationally-defined bacterial consortia in powder form.

Vedanta Biosciences’ pioneering work, in collaboration with its scientific co-founders, has led to the identification of human commensal bacteria that induce a range of immune responses – including induction of regulatory T cells, CD8+ T cells, and Th17 cells, among others. These advances have been published in leading peer-reviewed journals including Science (multiple), Nature (multiple), Cell and Nature Immunology. Vedanta Biosciences has harnessed these biological insights and its capabilities to generate a pipeline of programs in infectious disease, autoimmune disease, allergy, and immune-oncology.